C. M. Moore

How do host population dynamics impact Lyme disease risk dynamics in theoretical models?

This study uses a theoretical model to show that host population dynamics significantly affect Lyme disease risk metrics like nymphal infection prevalence and density of infected nymphs.

Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis in mice

This study develops a targeted amplification RNA sequencing method, SEARCH-TB, to analyze Mycobacterium tuberculosis transcriptomes in mice during treatment, revealing transcriptional adaptations including metabolic shifts and regulatory reprogramming.

Depletion Assisted Hemin Affinity (DAsHA) Proteomics Reveals an Expanded Landscape of Heme Binding Proteins

The paper introduces a chemoproteomics method to identify heme-binding proteins, revealing new roles for heme in chromatin remodeling, DNA repair, RNA splicing, and vesicular trafficking.

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function

The paper identifies IL-13-programmed airway tuft cells that produce PGE2, which enhances CFTR-dependent mucociliary function in allergic airways.

Combination of Mycobacterium tuberculosis RS ratio and CFU improves the ability of murine efficacy experiments to distinguish between drug treatments

Selective inhibition of PfATP6 by artemisinins and identification of new classes of inhibitors after expression in yeast

The paper develops a yeast-based screening tool to identify PfATP6 inhibitors, confirming artemisinins target PfATP6 and discovering new inhibitor classes.

Heme oxygenase-2 (HO-2) binds and buffers labile heme, which is largely oxidized, in human embryonic kidney cells

This study shows HO-2 binds and buffers oxidized labile heme in HEK293 cells, regulating heme homeostasis by controlling bioavailability rather than degrading heme under non-stress conditions.

Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability

This study shows human ribosomes form G-quadruplexes in vivo that regulate heme bioavailability through interactions with G4 ligands and heme sensors.

Population dynamics of mutualism and intraspecific density dependence: how θ-logistic density dependence affects mutualistic positive feedback

The paper examines how θ-logistic density dependence affects mutualistic positive feedback and shows that decelerating density dependence can prevent unbounded growth in mutualistic populations.

The mismatch in distributions of vertebrates and the plants that they disperse

This study examines the co-distribution of plant and animal mutualists, finding no significant correlation between seed dispersal mutualisms and species richness, with environmental factors being better predictors.