A. A. Bauman

Use of Multiple Pharmacodynamic Measures to Deconstruct the Nix-TB Regimen in a Short-Course Murine Model of Tuberculosis

The paper evaluates the Nix-TB regimen in a murine TB model using pharmacodynamic markers to assess drug contributions and interactions.

Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis in mice

This study develops a targeted amplification RNA sequencing method, SEARCH-TB, to analyze Mycobacterium tuberculosis transcriptomes in mice during treatment, revealing transcriptional adaptations including metabolic shifts and regulatory reprogramming.

Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses

The paper shows that Mycobacterium tuberculosis in different lung microenvironments have distinct phenotypes and treatment responses in a mouse model.

Combination of Mycobacterium tuberculosis RS ratio and CFU improves the ability of murine efficacy experiments to distinguish between drug treatments

Mechanism of selectivity reveals novel antifolate drug interactions

This study investigates PAS selectivity and finds it can antagonize sulfonamides and cause GI toxicity, suggesting caution in co-treatment for HIV-AIDS/M. tuberculosis co-infected individuals.

Methionine antagonizes para-aminosalicylic acid activity via affecting folate precursor biosynthesis pathway in Mycobacterium tuberculosis

This study identifies methionine's role in antagonizing PAS activity by affecting folate precursor biosynthesis in M. tuberculosis.