Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist
H. Huang, J. Liu, M. Rückborn, V. T. K. Le-Trilling, D. Zhu, S. Yang, W. Zhou, X. Yang, X. Feng, Y. Lu, M. Lu, U. Dittmer, D. Yang, M. Trilling
This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.
bioRxiv · Jan 29, 2020Immunology