RexAB is essential for the mutagenic repair of Staphylococcus aureus DNA damage caused by co-trimoxazole
R. S. Clarke, M. S. Bruderer, K. P. Ha, A. M. Edwards
This study shows that co-trimoxazole causes DNA damage in S. aureus through thymidine limitation and oxidative stress, which is repaired by the RexAB complex, leading to mutagenesis and antibiotic resistance.
bioRxiv · May 7, 2019Microbiology