Author

R. S. Clarke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Assay:DNA methylation· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. M. Edwards· 3 shared K. P. Ha· 3 shared A. H. Nobbs· 1 shared D. Mavridou· 1 shared D. Parker· 1 shared G.-L. Kim· 1 shared J. E. Rowley· 1 shared J. L. Brittan· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMicrobiology

A. M. Edwards

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multiple classes of bactericidal antibiotics cause DNA double strand breaks in Staphylococcus aureus

R. S. Clarke, K. P. Ha, A. M. Edwards

This study shows that multiple antibiotic classes induce DNA double strand breaks in Staphylococcus aureus, which are repaired by the RexAB complex, enhancing bacterial survival.

bioRxiv · Mar 5, 2021 · PreprintMicrobiology

Staphylococcal DNA repair is required for infection

K. P. Ha, R. S. Clarke, G.-L. Kim, J. L. Brittan, J. E. Rowley, D. Mavridou, D. Parker, T. B. Clarke, A. H. Nobbs, A. M. Edwards

This study identifies DNA repair mechanisms in Staphylococcus aureus essential for survival during infection, showing that host immune cells induce DNA damage repaired by RexAB.

bioRxiv · Feb 23, 2020Microbiology

RexAB is essential for the mutagenic repair of Staphylococcus aureus DNA damage caused by co-trimoxazole

R. S. Clarke, M. S. Bruderer, K. P. Ha, A. M. Edwards

This study shows that co-trimoxazole causes DNA damage in S. aureus through thymidine limitation and oxidative stress, which is repaired by the RexAB complex, leading to mutagenesis and antibiotic resistance.

bioRxiv · May 7, 2019Microbiology