Genomic evolution of non-small cell lung cancer patient-derived xenograft models
R. E. Hynds, A. Huebner, D. R. Pearce, A. U. Akarca, D. A. Moore, S. Ward, K. H. C. Gowers, T. Karasaki, M. S. Hill, M. Al Bakir, G. A. Wilson, O. Pich, M. Sivakumar, A. Ben Aissa, E. Gronroos, , C. Swanton
This study examines how well PDX models capture intratumour heterogeneity in NSCLC, finding that most models originate from a single subclone but regional models can capture diversity.
bioRxiv · Jan 6, 2023Cancer Biology