Optimized CRISPR-mediated gene knock-in reveals FOXP3-independent control of human Treg identity
A. J. Lam, D. T. S. Lin, J. K. Gillies, P. Uday, A. M. Pesenacker, M. S. Kobor, M. K. Levings
This study optimizes CRISPR-mediated gene knock-in in human Tregs and shows FOXP3 has a limited role in maintaining mature Treg identity.
bioRxiv · Jan 16, 2021Immunology