Author

A. J. Lam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. K. Gillies· 3 shared M. K. Levings· 3 shared P. Uday· 3 shared A. Gennerich· 1 shared A. M. Pesenacker· 1 shared C. M. Wardell· 1 shared D. T. S. Lin· 1 shared D. W. Nowakowski· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

J. K. Gillies

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PTEN is required for human Treg suppression of costimulation

A. J. Lam, M. Haque, K. A. Ward-Hartstonge, P. Uday, C. M. Wardell, J. K. Gillies, M. Speck, M. Mojibian, R. I. K. Geltink, M. K. Levings

This study shows PTEN is not essential for general Treg function but is required for their ability to suppress costimulatory molecule expression by antigen-presenting cells.

bioRxiv · Mar 6, 2022 · PreprintImmunology

Helios is a marker, not a driver, of human Treg stability

A. J. Lam, P. Uday, J. K. Gillies, M. K. Levings

The paper shows that Helios expression marks, but does not drive, human Treg stability in vitro, using CRISPR/Cas9 and in vitro expansion systems.

bioRxiv · Apr 27, 2021Immunology

Optimized CRISPR-mediated gene knock-in reveals FOXP3-independent control of human Treg identity

A. J. Lam, D. T. S. Lin, J. K. Gillies, P. Uday, A. M. Pesenacker, M. S. Kobor, M. K. Levings

This study optimizes CRISPR-mediated gene knock-in in human Tregs and shows FOXP3 has a limited role in maintaining mature Treg identity.

bioRxiv · Jan 16, 2021Immunology

A Highly Conserved 310-Helix Within the Kinesin Motor Domain is Critical for Kinesin Function and Human Health.

A. J. Lam, L. Rao, Y. Anazawa, K. Okada, K. Chiba, S. Niwa, A. Gennerich, D. W. Nowakowski, R. J. McKenney

This study identifies a conserved 310-helix in KIF1A critical for motor function and human health, showing that the P305L mutation disrupts microtubule association and motor performance.

bioRxiv · Sep 22, 2020Biophysics