Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection
J. Guenthoer, M. Lilly, T. N. Starr, B. Dadonaite, K. N. Lovendahl, J. T. Croft, C. I. Stoddard, V. Chohan, S. Ding, F. Ruiz, M. S. Kopp, A. Finzi, J. D. Bloom, H. Y. Chu, K. K. Lee, J. Overbaugh
This study identifies four broad, potent monoclonal antibodies against SARS-CoV-2 spike protein that neutralize multiple variants, including Omicron and XBB.1.5, targeting conserved regions with high functional constraint.
bioRxiv · Dec 15, 2022 · PreprintImmunology