B. Dadonaite

Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination

This study compares IgG antibody responses from SARS-CoV-2 infection, vaccination, and hybrid immunity, finding that hybrid immunity retains the imprint of the initial exposure and enhances antibody breadth and affinity.

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

This paper computationally redesigns an antibody to restore potency against SARS-CoV-2 Omicron subvariants while maintaining efficacy against Delta and other variants.

Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern

The paper designs bispecific antibodies that retain neutralization activity against multiple SARS-CoV-2 variants, including Omicron subvariants.

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades

This study uses deep mutational scanning to assess how mutations in SARS-CoV-2 spike proteins affect ACE2 binding, cell entry, and serum escape, linking these effects to clade growth rates.

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning

This study maps the neutralizing specificity of human anti-HIV serum using deep mutational scanning to identify Env mutations affecting neutralization by polyclonal sera.

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection

This study identifies four broad, potent monoclonal antibodies against SARS-CoV-2 spike protein that neutralize multiple variants, including Omicron and XBB.1.5, targeting conserved regions with high functional constraint.

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

This paper introduces a pseudovirus system for deep mutational scanning of SARS-CoV-2 spike protein mutations, showing how they affect antibody neutralization and infection.

Influenza virus transcription and progeny production are poorly correlated in single cells

This study measures both viral transcription and progeny production in single influenza-infected cells, finding they are poorly correlated.

Receptor binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2

This study shows that RBD antibodies contribute more to SARS-CoV-2 neutralization when target cells have high ACE2 expression, highlighting ACE2 levels as a critical experimental factor.

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

The paper analyzes epistatic shifts in SARS-CoV-2 RBD mutations across variants to understand how they influence ACE2 binding and future evolution.

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

The structure of the influenza A virus genome

This study maps RNA-RNA interactions in influenza A virus genomes, revealing a structured genome and redundant interactions that enable reassortment and packaging selectivity.