Discovery of the first selective M4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy
M. S. Moehle, A. M. Bender, J. W. Dickerson, D. J. Foster, Y. Donsante, W. Peng, Z. K. Bryany, T. M. Bridges, S. Chang, K. J. Watson, J. C. O'Neill, J. L. Engers, L. Peng, A. Rodriguez, C. M. Niswender, , J. M. Rook
This paper discovers the first selective M4 muscarinic acetylcholine receptor antagonists and confirms their anti-parkinsonian and anti-dystonic efficacy in rodent models.
bioRxiv · Oct 12, 2020 · PreprintPharmacology & Toxicology