Author

C. W. Lindsley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Pharmacology & Toxicology· 4

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Christopoulos· 2 shared C. M. Niswender· 2 shared C. Valant· 2 shared D. M. Thal· 2 shared E. T. van der Westhuizen· 2 shared G. Thompson· 2 shared P. J. Conn· 2 shared W. A. C. Burger· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Christopoulos

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4 papers

Recent·Most cited

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Z. Vuckovic, J. Wang, V. Pham, J. I. Mobbs, M. J. Belousoff, A. Bhattarai, W. A. C. Burger, G. Thompson, M. Yeasmin, K. Leach, E. T. van der Westhuizen, E. Khajehali, Y.-L. Liang, A. Glukhova, D. Wootten, , D. M. Thal

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

bioRxiv · Sep 27, 2022Pharmacology & Toxicology

Activating mGlu3 metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus.

S. Dogra, B. J. Stansley, Z. Xiang, W. Qian, R. G. Gogliotti, F. Nicoletti, C. W. Lindsley, C. M. Niswender, M. E. Joffe, P. J. Conn

This study shows that activating mGlu3 receptors in hippocampal pyramidal cells improves cognitive function in mice by inducing metaplastic changes that enhance synaptic plasticity.

bioRxiv · Oct 27, 2020Pharmacology & Toxicology

Discovery of the first selective M4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy

M. S. Moehle, A. M. Bender, J. W. Dickerson, D. J. Foster, Y. Donsante, W. Peng, Z. K. Bryany, T. M. Bridges, S. Chang, K. J. Watson, J. C. O'Neill, J. L. Engers, L. Peng, A. Rodriguez, C. M. Niswender, , J. M. Rook

This paper discovers the first selective M4 muscarinic acetylcholine receptor antagonists and confirms their anti-parkinsonian and anti-dystonic efficacy in rodent models.

bioRxiv · Oct 12, 2020 · PreprintPharmacology & Toxicology

Crystal structure of the M5 muscarinic acetylcholine receptor

Z. Vuckovic, P. R. Gentry, A. E. Berizzi, K. Hirata, S. Varghese, G. Thompson, E. T. van der Westhuizen, W. A. C. Burger, R. Rahmani, C. Valant, C. J. Langmead, C. W. Lindsley, J. Baell, A. B. Tobin, P. M. Sexton, , D. M. Thal

The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.

bioRxiv · Aug 14, 2019Pharmacology & Toxicology