Author

Y. Donsante

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. M. Bender· 1 shared A. M. Downs· 1 shared A. Rodriguez· 1 shared C. M. Niswender· 1 shared C. W. Lindsley· 1 shared D. J. Foster· 1 shared E. J. Hess· 1 shared H. A. Jinnah· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. M. Bender

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BLOCKADE OF M4 MUSCARINIC RECEPTORS ON STRIATAL CHOLINERGIC INTERNEURONS NORMALIZES STRIATAL DOPAMINE RELEASE IN A MOUSE MODEL OF DYT1-TOR1A DYSTONIA

A. M. Downs, Y. Donsante, H. A. Jinnah, E. J. Hess

This study identifies M4 muscarinic receptors on striatal cholinergic interneurons as key targets of THP in normalizing dopamine release in a DYT1 dystonia mouse model.

bioRxiv · Dec 17, 2020Pharmacology & Toxicology

Discovery of the first selective M4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy

M. S. Moehle, A. M. Bender, J. W. Dickerson, D. J. Foster, Y. Donsante, W. Peng, Z. K. Bryany, T. M. Bridges, S. Chang, K. J. Watson, J. C. O'Neill, J. L. Engers, L. Peng, A. Rodriguez, C. M. Niswender, , J. M. Rook

This paper discovers the first selective M4 muscarinic acetylcholine receptor antagonists and confirms their anti-parkinsonian and anti-dystonic efficacy in rodent models.

bioRxiv · Oct 12, 2020 · PreprintPharmacology & Toxicology