Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry
C.-C. Lee, T. M. Kono, F. Syed, S. A. Weaver, P. Sohn, W. Wu, G. Chang, J. Liu, M. S. Rupnik, C. Evans-Molina
This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.
bioRxiv · Dec 6, 2023 · PreprintPhysiology