Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state
B. Augustynek, G. Gyimesi, J. Dernic, M. Sallinger, G. Albano, G. J. Klesse, P. Kandasamy, H. Grabmayr, I. Frischauf, D. G. Fuster, C. Peinelt, M. A. Hediger, R. Bhardwaj
The paper investigates the gating mechanisms of Orai calcium channel paralogs by analyzing constitutively active mutants that mimic STIM1-gated states, revealing differences in conservation across paralogs.
bioRxiv · Oct 26, 2021 · PreprintCell Biology