Author

R. Schober

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1

Frequent Co-Authors

C. Seguin-Devaux· 2 shared G. Iserentant· 2 shared M. Moutschen· 2 shared A. Tiffner· 1 shared B. Brandus· 1 shared C. Hoeglinger· 1 shared C. Romanin· 1 shared D. Bonhenry· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

C. Seguin-Devaux

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Natural Killer activating Multimeric Immunotherapeutic compleXes (NaMiX) induce cytotoxic activity and killing of HIV-1 infected cells

R. Schober, B. Brandus, T. Laeremans, G. Iserentant, G. Dessilly, J. Zimmer, M. Moutschen, J. L. Aerts, X. Dervillez, C. Seguin-Devaux

This study develops NaMiX, multimeric immunotherapeutics targeting NK cell checkpoints, which enhance NK cell cytotoxicity against HIV-1 infected cells and reduce viral DNA in mice.

bioRxiv · Nov 11, 2022 · PreprintImmunology

The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load and total HIV-1 DNA in HIV-1 infected humanized mice

M. Amand, P. Adams, R. Schober, G. Iserentant, J.-Y. Servais, M. Moutschen, C. Seguin-Devaux

bioRxiv · Sep 1, 2022Immunology

A series of Orai1 gating checkpoints in transmembrane and cytosolic regions requires clearance for CRAC channel opening

A. Tiffner, R. Schober, C. Hoeglinger, D. Bonhenry, S. Pandey, V. Lunz, m. Sallinger, I. Frischauf, M. Fahrner, S. Lindinger, L. Maltan, S. Berlansky, M. Stadlbauer, R. Schindl, R. Ettrich, , I. Derler

This study identifies Orai1 gating checkpoints that must be cleared for CRAC channel opening, using a library of double mutants and structural analysis.

Journal of Biological Chemistry · Jan 1, 2021Peer-reviewedBiophysics