Author

M. Shimobayashi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. N. Hall· 4 shared D. Weissenberger· 3 shared I. C. Frei· 3 shared D. Ritz· 2 shared T. Maier· 2 shared A. C. Meyer-Gerspach· 1 shared A. Scaiola· 1 shared A. Thomas· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersPhysiology

M. N. Hall

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4 papers

Recent·Most cited

Hepatic mTORC2 compensates for loss of adipose mTORC2 in mediating energy storage and glucose homeostasis

I. C. Frei, D. Weissenberger, C. Muller, M. N. Hall, M. Shimobayashi

This study shows that loss of adipose mTORC2 leads to increased hepatic lipogenesis and hypertriglyceridemia, but simultaneous inhibition in both tissues causes severe insulin resistance.

bioRxiv · Dec 21, 2022Physiology

Adipose mTORC2 is essential for arborization of sensory neurons in white adipose tissue and whole-body energy homeostasis

I. C. Frei, D. Weissenberger, D. Ritz, W. Heusermann, M. Colombi, M. Shimobayashi, M. N. Hall

The paper identifies adipose mTORC2's role in sensory neuron arborization in white adipose tissue and links it to systemic insulin resistance.

bioRxiv · Mar 21, 2022 · PreprintPhysiology

The 3.2A resolution structure of human mTORC2

A. Scaiola, F. Mangia, S. Imseng, D. Boehringer, K. Berneiser, M. Shimobayashi, E. Stuttfeld, M. N. Hall, N. Ban, T. Maier

This study presents a 3.2 Å resolution cryo-EM structure of human mTORC2, revealing structural features and regulatory mechanisms.

bioRxiv · Apr 10, 2020 · PreprintBiochemistry

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia

M. Shimobayashi, S. Shetty, I. C. Frei, B. K. Wölnerhanssen, D. Weissenberger, N. Dietz, A. Thomas, D. Ritz, A. C. Meyer-Gerspach, T. Maier, N. Hay, R. Peterli, N. Rohner, M. N. Hall

The paper shows that loss of Hexokinase 2 in adipose tissue due to high fat diet leads to hyperglycemia through systemic glucose homeostasis disruption.

bioRxiv · Dec 28, 2019Physiology