Author

N. Hay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:metabolism & bioenergetics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

X. Chen· 2 shared A. A. C. Hooft van Huysduynen· 1 shared A. B. M. M. K. Islam· 1 shared A. C. Meyer-Gerspach· 1 shared A. Forrest· 1 shared A. Franzke· 1 shared A. Guggisberg· 1 shared A. Harkess· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

X. Chen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes

B. Paradoski, S. Hou, E. Mejia, F. Adefemi-Olayinka, D. Fowke, G. M. Hatch, A. Saleem, V. Banerji, N. Hay, H. Zeng, A. Marshall

This study shows that PI3K-dependent upregulation of hexokinase 2 (HK2) controls glucose metabolism and immune functions in B cells, with HK2-deficient B cells showing impaired metabolic and functional responses.

bioRxiv · Feb 29, 2024Immunology

Global Phylogeny of the Brassicaceae Provides Important Insights into Gene Discordance

K. P. Hendriks, C. Kiefer, I. A. Al-Shehbaz, C. D. Bailey, A. A. C. Hooft van Huysduynen, L. Nikolov, L. Nauheimer, A. R. Zuntini, D. A. German, A. Franzke, M. A. Koch, M. A. Lysak, O. Toro-Nunez, B. Ozudogru, V. R. Invernon, , Fore

This paper presents a comprehensive Brassicaceae phylogeny, identifies cytonuclear discordance due to hybridization, and proposes new tribes, providing a tool for biodiversity and plant biology studies.

bioRxiv · Sep 1, 2022Evolutionary Biology

A novel non-catalytic scaffolding activity of Hexokinase 2 contributes to EMT and metastasis

N. Hay

This study identifies a non-catalytic scaffolding role of HK2 that promotes EMT and metastasis by modulating GSK3 activity and SNAIL stability in breast cancer.

bioRxiv · Apr 8, 2021Cancer Biology

Cell autonomous versus systemic Akt isoform deletions uncovered new roles for Akt1 and Akt2 in breast cancer

N. Hay, X. Chen, M. M. Ariss, G. Ramakrishnan, V. Nogueira, C. Blaha, W. Putzbach, A. B. M. M. K. Islam, M. V. Frolov

The paper compares cell autonomous and systemic Akt1/Akt2 deletion effects in breast cancer, finding distinct roles in tumorigenesis and metastasis.

bioRxiv · Jan 8, 2020Cancer Biology

Identifying strategies to target the metabolic flexibility of tumours.

A. Mendez-Lucas, W. Lin, P. C. Driscoll, N. Legrave, L. Novellasdemunt Vilaseca, C. Xie, M. Charles, Z. Wilson, N. P. Jones, S. G. Rayport, M. Rodriguez-Justo, V. S. W. Li, J. I. MacRae, N. Hay, X. Chen, M. Yuneva

The paper identifies compensatory metabolic mechanisms in tumours and shows that targeting these can improve therapeutic outcomes.

bioRxiv · Jan 6, 2020Cancer Biology

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia

M. Shimobayashi, S. Shetty, I. C. Frei, B. K. Wölnerhanssen, D. Weissenberger, N. Dietz, A. Thomas, D. Ritz, A. C. Meyer-Gerspach, T. Maier, N. Hay, R. Peterli, N. Rohner, M. N. Hall

The paper shows that loss of Hexokinase 2 in adipose tissue due to high fat diet leads to hyperglycemia through systemic glucose homeostasis disruption.

bioRxiv · Dec 28, 2019Physiology