Hepatic mTORC2 compensates for loss of adipose mTORC2 in mediating energy storage and glucose homeostasis
I. C. Frei, D. Weissenberger, C. Muller, M. N. Hall, M. Shimobayashi
This study shows that loss of adipose mTORC2 leads to increased hepatic lipogenesis and hypertriglyceridemia, but simultaneous inhibition in both tissues causes severe insulin resistance.
bioRxiv · Dec 21, 2022Physiology