Author

M. Shimomura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

A. A. Vinogradov· 2 shared H. Onaka· 2 shared H. Suga· 2 shared Y. Goto· 2 shared N. Kano· 1 shared S. Asamizu· 1 shared T. Ozaki· 1 shared Y. Sugai· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

A. A. Vinogradov

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2 papers

Recent·Most cited

Promiscuous enzymes cooperate at the substrate level en route to lactazole A

A. A. Vinogradov, M. Shimomura, N. Kano, Y. Goto, H. Onaka, H. Suga

This study investigates the biosynthesis of lactazole A, revealing dynamic enzyme cooperation and kinetic control in thiopeptide assembly using an in vitro system.

bioRxiv · May 12, 2020Biochemistry

Minimal lactazole scaffold for in vitro production of pseudo-natural thiopeptides

A. A. Vinogradov, M. Shimomura, Y. Goto, T. Ozaki, S. Asamizu, Y. Sugai, H. Suga, H. Onaka

This paper develops a platform for in vitro biosynthesis of lactazole A, enabling the creation of diverse thiopeptide analogs with modified structures.

bioRxiv · Oct 16, 2019 · PreprintBiochemistry