Y. Goto

Addressing anemia severity in antimony-resistant Leishmania donovani infection at the nexus of oxidative outburst and iron transit

This study investigates how antimony-resistant Leishmania donovani strains manage iron and oxidative stress, leading to anemia, and identifies potential therapeutic targets.

Designing monomeric IFNγ: the significance of domain-swapped dimer structure in IFNγ immune responses

This study designs a monomeric IFNγ by modifying its domain-swapped dimer structure, showing it retains a similar balance of immunostimulatory and immunosuppressive gene expression as wild-type IFNγ.

Live-cell fluorescence imaging and optogenetic control of PKA kinase activity in fission yeast Schizosaccharomyces pombe.

This paper develops a biosensor to visualize and manipulate PKA activity in fission yeast, revealing its dynamics during cell cycle phases.

The leucine-rich repeat receptor kinase QSK1 is a novel regulator of PRR-RBOHD complex and is employed by the bacterial effector HopF2Pto to modulate plant immunity

The paper identifies QSK1 as a novel negative regulator of PRR-RBOHD complex and shows it is targeted by the bacterial effector HopF2Pto to suppress plant immunity.

Genetically-clustered antifungal phytocytokines and receptor proteins function together to trigger plant immune signaling

This study identifies genetically-clustered antifungal phytocytokines and their receptor proteins in poplar and willow, showing they function together to trigger immune signaling.

RudLOV-a new optically synchronized cargo transport method reveals unexpected effect of dynasore

The paper introduces RudLOV, an optical method for synchronized cargo release, revealing dynasore's differential effects on early and late Golgi transport.

Cytoplasmic fluidization triggers breaking spore dormancy in fission yeast.

This study identifies a signaling pathway in fission yeast spores that fluidizes the cytoplasm during dormancy breaking, enabling rapid cellular responses to glucose.

A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC

This study identifies mTOR inhibition as a way to prevent adaptive resistance to CDK4/6 blockade in HNSCC by targeting cell cycle pathways.

Live-cell imaging provides direct evidence for a threshold in CDK activity at the G2/M transition

The paper uses live-cell imaging to show CDK activity reaches a threshold at G2/M transition in fission yeast and mammalian cells.

Wandering albatrosses exert high take-off effort only when both wind and waves are gentle

This study estimates wind and wave conditions experienced by wandering albatrosses using animal-borne sensors and finds that take-off effort is highest when both wind and waves are gentle.

Albatrosses employ orientation and routing strategies similar to yacht racers

This study compares the navigation strategies of wandering albatrosses and yacht racers, finding similar wind-optimized travel patterns despite differences in time-minimization.

Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

This study demonstrates that 2-bromopropane induces lung tumors and testicular toxicity in rasH2 mice after 26 weeks of inhalation exposure.

Discovery of intratumoral oncolytic bacteria toward targeted anticancer theranostics

The paper identifies intratumoral bacteria with therapeutic potential, showing they induce strong anticancer responses and enable tumor diagnosis through light-harvesting nanocomplexes.

Using eDNA metabarcoding to establish targets for freshwater fish composition following river restoration

This study uses eDNA metabarcoding to identify fish community composition and set realistic targets for a river restoration project, finding more species than traditional capture surveys.

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

This study investigates pulmonary lesions in rats exposed to titanium dioxide nanoparticles, identifying a new lesion type called pulmonary dust foci associated with pneumoconiosis-like effects.

Accurate models of substrate preferences of post-translational modification enzymes from a combination of mRNA display and deep learning

The paper develops a platform combining mRNA display and deep learning to accurately model substrate preferences of PTM enzymes, showing high accuracy and complexity in enzyme specificity.

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

This study identifies serum albumin concentration as a tertiary risk factor for dialysis-related amyloidosis, showing that maintenance dialysis improves outcomes by increasing serum component concentrations.

Single mutation makes Escherichia coli an insect mutualist

The paper shows that a single mutation in E. coli enables it to become an insect mutualist by disrupting carbon catabolite repression.

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.

Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

This study shows titanium dioxide nanoparticles do not cause lung fibrosis or cancer in rasH2 mice after 26 weeks of inhalation exposure up to 32 mg/m3.

Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers

This study examines lung damage in rats exposed to cross-linked water-soluble acrylic acid polymers (CWAAPs) via inhalation and intratracheal instillation, finding similar pathological outcomes between exposure routes.

Quantitative live-cell fluorescence imaging of GPCR downstream signaling dynamics at the single-cell level.

The paper uses live-cell fluorescence imaging to study GPCR downstream signaling dynamics, revealing heterogeneity among receptors and cells.

Near-infrared imaging in fission yeast by genetically encoded biosynthesis of phycocyanobilin

This paper demonstrates that phycocyanobilin enhances iRFP fluorescence in fission yeast, enabling live-cell near-infrared imaging through engineered biosynthesis systems.

The phagocytosis oxidase/Bem1p (PB1) domain-containing protein PB1CP negatively regulates the NADPH oxidase RBOHD in plant immunity

This study identifies PB1CP as a negative regulator of RBOHD in plant immunity, showing it relocalizes RBOHD from the plasma membrane to endomembrane compartments.

Soaring styles of extinct giant birds and pterosaurs

The paper quantifies the flight performance and wind requirements of extinct giant birds and pterosaurs, finding conflicting results with previous studies on their soaring styles.

Human trans-editing enzyme displays tRNA acceptor stem specificity and relaxed amino acid selectivity

This study examines how human ProXp-ala recognizes tRNA acceptor stem elements and amino acids, showing specificity changes compared to bacterial enzymes.

Multistep changes in amyloid structure that are induced by cross-seeding on a rugged energy landscape

This study investigates how cross-seeding of insulin amyloid fibrils from different species leads to structural changes and new amyloid forms with distinct properties.

Development of optogenetic tools to manipulate cell cycle checkpoints

This study develops optogenetic tools to control cell-cycle checkpoints using phytochrome B in fission yeast, enabling light-induced arrest and release of G2/M and SAC checkpoints.

A genetically encoded red fluorescence dopamine biosensor enables dual imaging of dopamine and norepinephrine

This paper develops a red fluorescent dopamine biosensor with high selectivity over norepinephrine, enabling dual-color imaging of both neuromodulators in vitro.