New Insights into the Mechanisms Used by Inhibitors Targeting Glutamine Metabolism in Cancer Cells
S. K. Milano, Q. Huang, T.-T. T. Nguyen, S. Ramachandran, A. Finke, I. Kriksunov, D. Schuller, M. Szebenyi, E. Arenholz, L. A. McDermott, N. Sukumar, R. A. Cerione, W. P. Katt
The paper investigates the mechanism of action of GAC inhibitors using crystallography and computational models, revealing conformational differences that affect potency.
bioRxiv · Sep 20, 2021 · PreprintBiochemistry