Q. Huang

Gn1a rice promotes symbiotic fish growth via reprogramming soil microbiome

This study shows that mutating the Gn1a gene in rice increases cytokinin levels, which enhances fish growth and immunity by altering soil microbiota and gut microbial composition.

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

Double-stranded RNA induces retinal pigment epithelium cell degeneration and inflammation

This study shows dsRNA triggers RIG-I signaling, leading to inflammation and RPE degeneration in AMD, with implications for pathogenesis.

GhCPK28 negatively regulates the immune response by phosphorylating GhTIFY3b

This study identifies GhCPK28 as a negative regulator of cotton immunity against Verticillium dahliae by phosphorylating and destabilizing GhTIFY3b, enhancing resistance when silenced.

YAP promotes chromosomal instability by transcriptionally activating AJUBA through its super enhancer in breast cancer

This study identifies YAP's role in promoting chromosomal instability in breast cancer by activating AJUBA through its super enhancer, leading to AURKA activation and aberrant mitosis.

ARBUR, a machine learning-based analysis system for relating behaviors and ultrasonic vocalizations of rats

ARBUR is a machine learning system that clusters rat ultrasonic vocalizations and detects social behaviors, revealing communication patterns and novel findings in social interactions.

Identification of Antigen-Specific T Cell Receptors with combinatorial peptide pooling

This paper introduces copepodTCR, a tool for designing and interpreting TCR specificity assays, which efficiently identifies antigen-specific TCRs using combinatorial peptide pooling and Bayesian modeling.

MFSD7c functions as a transporter of choline at the blood-brain barrier

This study identifies MFSD7c as a choline transporter at the blood-brain barrier and links its dysfunction to Fowler syndrome.

Commensal microbiome dysbiosis elicits IL-8 signaling to drive fibrotic skin disease

The paper investigates the role of commensal microbiome dysbiosis in keloid fibrosis, finding elevated IL-8 signaling drives collagen accumulation and fibroblast migration.

Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning

This study identifies S1PR4 as a key immune modulator linked to better prognosis in HNSCC through machine learning-based subtype classification and functional analysis.

The canonical single-stranded DNA binding protein SSB is not an essential replication protein but an RNA chaperon in the hyperthermophilic archaeon Saccharolobus islandicus REY15A

This study shows that the canonical SSB in Saccharolobus islandicus REY15A is not essential for DNA replication but functions as an RNA chaperone, with conserved activities in related archaea.

Transcriptional changes consistent with altered neuronal differentiation, angiogenesis, and tumor plasticity induced in human subpallial telencephalic organoid-glioblastoma chimeras.

This study investigates reciprocal interactions between human subpallial telencephalic organoids and GBM spheroids, identifying transcriptional changes linked to neuronal differentiation, angiogenesis, and tumor plasticity.

Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase

The paper compares the effects of high temperature and pressure on the structure of the phosphatase STEP, revealing distinct structural changes under each condition.

Dynamics of the epigenetic landscape during development and in response to drought stress in sorghum

This study identifies novel epigenomic features in sorghum, including H3K27me3 islands and the role of histone marks in regulating tissue-specific and stress-responsive genes.

Redefining hematopoietic progenitor cells and reforming the hierarchy of hematopoiesis

This study redefines hematopoietic progenitor cells and reformulates the hematopoiesis hierarchy using a transcriptional atlas, identifying key transcription factors and distinct lineage commitment processes.

Modeling multiphage-bacteria kinetics to predict phage therapy potency and longevity

This study models phage-bacteria interactions to predict the potency and longevity of phage cocktails against Pseudomonas aeruginosa.

Shape-shifting microgel automata controlled by DNA sequence instructions

The paper demonstrates DNA-controlled microgel automata that transform between complex shapes using designed DNA sequences and neural networks.

Accurate Detection of Proteins in Cryo-Electron Tomograms from Sparse Labels

This paper introduces a particle detection framework for cryo-electron tomograms that improves detection accuracy with minimal labeling and faster training.

The archaeal KEOPS complex possesses a functional Gon7 homolog and has an essential function independent of cellular t6A modification level

This study identifies the archaeal KEOPS complex subunits and shows its essential function independent of t6A modification.

Inline SAXS-coupled chromatography under extreme hydrostatic pressure

This study demonstrates that reproducible SEC-SAXS can be performed under extreme hydrostatic pressure up to 100 MPa, revealing pressure-induced changes in biomolecular structure and oligomeric state.

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models

This study compares chromatin remodeling in colorectal cancer patient-derived models and identifies transcription factors driving differences in growth and drug response.

A novel RHH family transcription factor aCcr1 and its viral homologs dictate cell cycle progression in archaea

This study identifies aCcr1, an archaeal transcription factor, and its viral homologs as regulators of cell cycle progression, showing they control cell division by repressing cdvA expression.

Candidate targets of copy number deletion events across 17 cancer types

This study identifies gene targets of copy number deletions across 17 cancer types using segmental breakpoints and shows common and cancer-specific pathways affected.

The complex roles of genomic DNA modifications of bacteriophage T4 in resistance to nuclease-based defense systems of E. coli

The paper investigates how genomic modifications in phage T4 DNA affect its resistance to nuclease-based defense systems in E. coli, revealing roles beyond simple DNA degradation prevention.

Automated systematic evaluation of cryo-EM specimens with SmartScope

SmartScope automates cryo-EM specimen evaluation using deep learning, improving efficiency and reducing manual effort in structure determination.

Autonomous untethered microinjectors for gastrointestinal delivery of insulin

This study develops autonomous microinjectors for GI delivery of insulin, showing they can deliver insulin systemically at levels comparable to intravenous administration.

MEIG1/PACRG associated and non-associated functions of axonemal dynein light intermediate polypeptide 1 (DNALI1) in mammalian spermatogenesis

This study identifies DNALI1 as a key protein in sperm development, showing its role in the MEIG1/PACRG complex for cargo transport along the manchette and its involvement in sperm individualization.

G6PD Inhibition Sensitizes Ovarian Cancer Cells to Oxidative Stress in the Metastatic Omental Microenvironment

This study shows G6PD inhibition increases oxidative stress and reduces omental metastases in ovarian cancer.