Author

S. K. Milano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

R. A. Cerione· 3 shared C. Aplin· 2 shared T.-T. T. Nguyen· 2 shared W. P. Katt· 2 shared A. Finke· 1 shared D. Ogunribido· 1 shared D. Schuller· 1 shared E. Arenholz· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiophysics

R. A. Cerione

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Author profile →

3 papers

Recent·Most cited

Defining the conformational states that enable transglutaminase 2 to promote cancer cell survival versus cell death

C. Aplin, K. A. Zielinski, S. Pabit, D. Ogunribido, W. P. Katt, L. Pollack, R. A. Cerione, S. K. Milano

This paper investigates the conformational states of TG2 and shows how an inhibitor stabilizes an open conformation that is cytotoxic to cancer cells.

bioRxiv · Feb 4, 2024 · PreprintBiophysics

Filament formation drives catalysis by glutaminase enzymes important in cancer progression

S. Feng, C. Aplin, T.-T. T. Nguyen, S. K. Milano, R. A. Cerione

This study shows that filament formation by glutaminase enzymes GAC and GLS2 is directly linked to their catalytic activity and presents cryo-EM structures revealing the conformational changes essential for glutaminolysis in cancer.

bioRxiv · Feb 16, 2023 · PreprintBiophysics

New Insights into the Mechanisms Used by Inhibitors Targeting Glutamine Metabolism in Cancer Cells

S. K. Milano, Q. Huang, T.-T. T. Nguyen, S. Ramachandran, A. Finke, I. Kriksunov, D. Schuller, M. Szebenyi, E. Arenholz, L. A. McDermott, N. Sukumar, R. A. Cerione, W. P. Katt

The paper investigates the mechanism of action of GAC inhibitors using crystallography and computational models, revealing conformational differences that affect potency.

bioRxiv · Sep 20, 2021 · PreprintBiochemistry