Investigating the NRAS 5' UTR as a Target for Small Molecules
S. Balaratnam, Z. R. Torrey, D. R. Calabrese, M. T. Banco, K. Yazdani, X. Liang, A. Ferre-D'Amare, D. Incarnato, J. S. Schneekloth
This study identifies a novel small molecule that binds to the NRAS mRNA G4 structure, showing in vitro translation inhibition but limited in vivo effects, highlighting transcript heterogeneity challenges.
bioRxiv · Jan 5, 2022Biochemistry