J. S. Schneekloth

Mechanistic Analysis of Riboswitch Ligand Interactions Provides Insights into Pharmacological Control over Gene Expression

This study investigates how different small molecules affect riboswitch activity by altering RNA conformation, showing distinct mechanisms in live cells.

Competitive Microarray Screening Reveals Functional Ligands for the DHX15 RNA G-quadruplex

The paper identifies a functional ligand for an RNA G-quadruplex in DHX15 mRNA using competitive microarray screening and shows it inhibits translation.

DECODING COMPLEXITY IN BIOMOLECULAR RECOGNITION OF DNA I-MOTIFS

The paper uses a DNA microarray to study how proteins and small molecules bind to DNA i-motifs, finding that hnRNP K broadly recognizes iMs while others prefer G-quadruplexes.

Machine Learning Informs RNA-Binding Chemical Space

This study introduces ROBIN, a large RNA-binding small molecule library, and uses machine learning to model RNA-binding chemical space.

Investigating the NRAS 5' UTR as a Target for Small Molecules

This study identifies a novel small molecule that binds to the NRAS mRNA G4 structure, showing in vitro translation inhibition but limited in vivo effects, highlighting transcript heterogeneity challenges.

Interrogating RNA-small molecule interactions with structure probing and AI augmented-molecular simulations

The paper uses AI-augmented molecular dynamics simulations to study RNA-ligand interactions, validating predictions of mutations affecting binding affinities in riboswitch systems.

Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands

The paper identifies small ligands that bind RNA packaging signals in Hepatitis B Virus, inhibiting nucleocapsid assembly and suggesting new anti-viral drug targets.