Author

K. Yazdani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. S. Schneekloth· 4 shared M. Yang· 2 shared S. Balaratnam· 2 shared A. Ferre-D'Amare· 1 shared C. R. Fullenkamp· 1 shared C. Vinson· 1 shared D. Incarnato· 1 shared D. Jordan· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBiochemistry

J. S. Schneekloth

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4 papers

Recent·Most cited

Competitive Microarray Screening Reveals Functional Ligands for the DHX15 RNA G-quadruplex

P. R. Prestwood, M. Yang, G. V. Lewis, S. Balaratnam, K. Yazdani, J. S. Schneekloth

The paper identifies a functional ligand for an RNA G-quadruplex in DHX15 mRNA using competitive microarray screening and shows it inhibits translation.

bioRxiv · Jul 25, 2023Biochemistry

DECODING COMPLEXITY IN BIOMOLECULAR RECOGNITION OF DNA I-MOTIFS

K. Yazdani, S. Seshadri, D. Tillo, C. Vinson, J. S. Schneekloth

The paper uses a DNA microarray to study how proteins and small molecules bind to DNA i-motifs, finding that hnRNP K broadly recognizes iMs while others prefer G-quadruplexes.

bioRxiv · Apr 19, 2023 · PreprintBiochemistry

Machine Learning Informs RNA-Binding Chemical Space

K. Yazdani, D. Jordan, M. Yang, C. R. Fullenkamp, T. E. H. Allen, R. T. Khan, J. S. Schneekloth

This study introduces ROBIN, a large RNA-binding small molecule library, and uses machine learning to model RNA-binding chemical space.

bioRxiv · Aug 1, 2022Biochemistry

Investigating the NRAS 5' UTR as a Target for Small Molecules

S. Balaratnam, Z. R. Torrey, D. R. Calabrese, M. T. Banco, K. Yazdani, X. Liang, A. Ferre-D'Amare, D. Incarnato, J. S. Schneekloth

This study identifies a novel small molecule that binds to the NRAS mRNA G4 structure, showing in vitro translation inhibition but limited in vivo effects, highlighting transcript heterogeneity challenges.

bioRxiv · Jan 5, 2022Biochemistry