X. Liang

Soil viruses reduce greenhouse gas emissions and promote microbial necromass accrual

This study shows soil viruses reduce greenhouse gas emissions and increase microbial necromass, influencing soil carbon storage through viral-mediated microbial mortality.

Auditory High Entropy Response (A-HER): A Novel Paradigm for Studying Brain Processing of Uncertain Information

The paper introduces A-HER, a paradigm that maximizes auditory stimulus entropy to study brain processing of uncertain information, showing improved signal-to-noise ratio and repeatability compared to other methods.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

LLPS condensates of Fha initiate the inside-out assembly of the type VI secretion system

This study identifies Fha as the initiator of T6SS assembly in Acidovorax citrulli, showing it forms LLPS condensates that recruit T6SS components, revealing an inside-first assembly model.

Dendritic cell-derived lncRNA in patients with acute coronary syndrome

This study examines lncRNA expression in monocyte-derived dendritic cells (moDC) across different ACS subtypes, identifying CCL15-CCL14 as a differentially expressed lncRNA that modulates moDC function.

FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

This study shows that FASlpr gene dosage affects lymphoproliferation and T cell differentiation in lupus models, with heterozygous Faslpr leading to increased autoantibodies and Th1 cell skewing.

MCAK Recognizes the Nucleotide-Dependent Feature at Growing Microtubule Ends

This study investigates how MCAK binds to growing microtubule ends using single-molecule imaging, revealing its nucleotide-dependent binding mechanism and interaction with other end-binding regulators.

Molecular mechanism of acid stress response of A. acidoterrestris DSM 3922T under sublethal pH environment

This study identifies differentially expressed proteins in A. acidoterrestris under sublethal pH stress, revealing key acid resistance mechanisms involving pH homeostasis, metabolism, and DNA repair.

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

Novel endogenous engineering platform for robust loading and delivery of functional mRNA by extracellular vesicles

This paper develops an mRNA delivery system using extracellular vesicles engineered with RNA-binding domains and fusogenic moieties, showing improved efficacy in a melanoma model.

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

Neurons Alter Endoplasmic Reticulum Exit Sites to accommodate Dendritic Arbor Size

This study shows that neurons adjust the number of endoplasmic reticulum exit sites (ERESs) based on dendritic arbor size in C. elegans, regulated by asymmetric cell division and nutrient sensing.

Curvature Sensing and Membrane Remodeling of the VPS37A N-terminal Domain during Autophagy

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

Not just with the natives, but phylogenetic relationship between stages of the invasion process determines invasion success of alien plant species

The paper tests Darwin's hypotheses on alien plant invasion success by analyzing phylogenetic relationships across invasion stages and environmental contexts.

Aberrant cell state plasticity mediated by developmental reprogramming precedescolorectal cancer initiation

The paper shows that aberrant cell state plasticity, driven by regenerative activity and developmental reprogramming, occurs before colorectal cancer initiation in mouse models and human patients.

Systematic mutagenesis reveals critical effector functions in the assembly and dueling of the H1-T6SS in Pseudomonas aeruginosa

This study systematically mutagenizes H1-T6SS effectors and VgrG proteins in Pseudomonas aeruginosa to reveal their roles in T6SS assembly and dueling responses.

A dueling-competent signal-sensing module guides precise delivery of cargo proteins into target cells by engineered Pseudomonas aeruginosa

This paper introduces a protein delivery platform called DUEC that selectively delivers cargo into target cells using engineered bacterial systems.

A point mutation in Chl biosynthesis gene Mg-chelatase I subunit influences on leaf color and metabolism in strawberry

This study identifies a point mutation in the CHLI gene of strawberry that affects leaf color and metabolism by reducing chlorophyll and flavonoid levels and altering light sensitivity.

A common mechanism of temperature-sensing in thermoTRP channels

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

KDM4A promotes the progression of neuroendocrine prostate cancer

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

Ultra-high-throughput microbial single-cell whole genome sequencing for genome-resolved metagenomics

This paper develops an ultra-high-throughput method for microbial single-cell whole genome sequencing to study microbial dark matter and improve metagenomic analysis.

Structural insights into the viral proteins binding by TRIM7 reveal a general C-terminal glutamine recognition mechanism

The paper identifies a C-terminal glutamine recognition mechanism by TRIM7 that targets viral proteins, revealing its role in antiviral defense against norovirus and SARS-CoV-2.

E. coli can eat DNA as excellent nitrogen source to grow quickly

This study shows E. coli can use DNA as a nitrogen source for growth, outperforming Bifidobacterium bifidum, and ingests long DNA directly without altering its length.

Conserved Untranslated Regions of Multipartite Viruses: Natural Markers of Novel Viral Genomic Components and Tags of Viral Evolution

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

Investigating the NRAS 5' UTR as a Target for Small Molecules

This study identifies a novel small molecule that binds to the NRAS mRNA G4 structure, showing in vitro translation inhibition but limited in vivo effects, highlighting transcript heterogeneity challenges.

Dynamic Instability of Dendrite Tips Generates the Highly Branched Morphologies of Sensory Neurons

This study shows that dynamic instability at dendrite tips generates complex branching in Drosophila sensory neurons through stochastic transitions between growth, shrinkage, and pause states.

Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.