Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy
S. Zborowsky, J. Seurat, Q. Balacheff, S. Ecomard, C. Mulet, C. N. N. Minh, M. Titecat, E. Evrard, R. A. Rodriguez-Gonzalez, J. Marchi, J. S. Weitz, L. Debarbieux
This study shows that macrophages reduce bacteriophage density in the lungs, limiting the effectiveness of phage therapy in treating Pseudomonas aeruginosa pneumonia.
bioRxiv · Jan 16, 2024Microbiology