L. Debarbieux

Metapopulation model of phage therapy of an acute Pseudomonas aeruginosa lung infection

This study uses a spatially structured metapopulation model and in vivo experiments to evaluate how lung anatomy and immune responses affect the efficacy of phage therapy for Pseudomonas aeruginosa infections.

Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy

This study shows that macrophages reduce bacteriophage density in the lungs, limiting the effectiveness of phage therapy in treating Pseudomonas aeruginosa pneumonia.

Predicting phage-bacteria interactions at the strain level from genomes

This paper predicts phage-bacteria interactions at the strain level using genomic data from Escherichia isolates and shows tailored phage cocktails are more effective.

Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

The paper shows that phages targeting protective gut bacteria increase susceptibility to Salmonella Typhimurium infection in gnotobiotic mice.

Variable effects on virulence of bacteriophage resistance mechanisms in extraintestinal pathogenic Escherichia coli

This study examines phage resistance mechanisms in E. coli and finds that resistance can be predicted from in vitro conditions, often reduces virulence, and can be mitigated with phage cocktails.

The selection of antibiotic- and bacteriophage-resistant Pseudomonas aeruginosa is prevented by their combination

This study shows that combining antibiotics and bacteriophages prevents the selection of resistant Pseudomonas aeruginosa clones in a hollow fiber infection model.

Chromosome folding and prophage activation reveal gut-specific genome dynamics of bacteria in the OMM12 consortium

The paper uses Hi-C to study chromosome folding and prophage activation in gut bacteria, identifying functional prophages and their environmental dynamics.

Combination of in vivo phage therapy data with in silico model highlights key parameters for treatment efficacy

The paper combines in vivo phage therapy data with an in silico model to identify key parameters affecting treatment efficacy in bacterial pneumonia.

Isolation and characterization of bacteriophages that infect Citrobacter rodentium, a model pathogen for investigating human intestinal diseases

The paper isolates and characterizes two new bacteriophages, CrRp3 and CrRp10, that infect Citrobacter rodentium, finding differences in their host range, lytic cycle, and response to hypoxia.

Optimizing the Timing and Composition of Therapeutic Phage Cocktails: A Control-theoretic Approach

This study uses control-theoretic principles to optimize phage cocktail timing and composition for bacterial infection treatment, showing that two-phage cocktails can restore efficacy in immunodeficient hosts.

The spatial heterogeneity of the gut limits bacteriophage predation leading to the coexistence of antagonist populations of bacteria and their viruses

The paper shows that spatial heterogeneity in the gut allows bacteria to coexist with their phages by providing refuge sites, challenging previous assumptions about phage-bacteria dynamics.

Human neutrophil response to Pseudomonas bacteriophages

This study shows that Pseudomonas phage PAK_P1 exposure increases IL-8 secretion in human neutrophils without affecting other effector responses.