B. Stecher

Contribution of bacterial and host factors to pathogen "blooming" in a gnotobiotic mouse model for Salmonella enterica serovar Typhimurium-induced enterocolitis

This study investigates how bacterial and host factors contribute to Salmonella 'blooming' in a gnotobiotic mouse model of enterocolitis, showing that inflammation and specific Salmonella traits influence microbial community shifts and pathogen abundance.

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.

Nutritional and host environments determine community ecology and keystone species in a synthetic gut bacterial community

The paper identifies keystone species in a synthetic gut bacterial community and shows their roles vary with nutritional and host environments.

A novel taurine-respiring murine gut bacterium contributes to colonization resistance against enteropathogens

The paper identifies and characterizes a new murine gut bacterium, Taurinivorans muris, which uses taurine respiration and contributes to colonization resistance against pathogens.

Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

The paper shows that phages targeting protective gut bacteria increase susceptibility to Salmonella Typhimurium infection in gnotobiotic mice.

Chromosome folding and prophage activation reveal gut-specific genome dynamics of bacteria in the OMM12 consortium

The paper uses Hi-C to study chromosome folding and prophage activation in gut bacteria, identifying functional prophages and their environmental dynamics.

Identification of two pyruvate transporters in Salmonella enterica serovar Typhimurium and their biological relevance

This study identifies two pyruvate transporters in Salmonella Typhimurium and shows their roles in chemotaxis, stress survival, and infection.

Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities

The paper expands a mouse gut microbiota collection to 212 strains, enabling the creation of custom synthetic communities and improving the Oligo-Mouse Microbiota model.

Metabolic reconstitution by a gnotobiotic microbiota varies over the circadian cycle

This study shows that a gnotobiotic microbiota affects metabolic processes differently depending on the circadian cycle, influencing energy balance and substrate utilization.

Exploring the interaction network of a synthetic gut bacterial community

This study investigates the interaction network of a synthetic gut bacterial community, revealing exploitative and interference competition shaping community dynamics.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

Helicobacter hepaticus as disease driver in a novel CD40-mediated model of colitis

This study identifies Helicobacter hepaticus as a disease driver in a CD40-mediated colitis model by showing its role in inducing inflammatory immune responses through specific antigen recognition.

A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes

The spatial heterogeneity of the gut limits bacteriophage predation leading to the coexistence of antagonist populations of bacteria and their viruses

The paper shows that spatial heterogeneity in the gut allows bacteria to coexist with their phages by providing refuge sites, challenging previous assumptions about phage-bacteria dynamics.

Local interactions lead to spatially correlated gene expression levels in bacterial groups.

The paper shows spatial correlations in gene expression among Escherichia coli cells due to local interactions and shared microenvironment.