BiochemistrybioRxiv
Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin
E. d'Amico, M. Ud Din Ahmad, V. Cmentowski…·A. Musacchio
The paper shows Spindly adopts a closed conformation that blocks Dynein-Dynactin binding, and mutations induce an open state that enables interaction, with kinetochores promoting Spindly activation.
DOI 10.1083/jcb.202206131