Author

A. P. Carter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8 Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell signaling & trafficking· 8 Organism:human· 4 Approach:microscopy & imaging analysis· 4 Research Focus:cell type annotation· 3 Assay:cryo-EM· 3 Organism:Drosophila· 3 Organism:mouse· 2

Frequent Co-Authors

C. E. Stone· 2 shared C. Ventura Santos· 2 shared E. Derivery· 2 shared H. E. Foster· 2 shared J. A. G. Briggs· 2 shared K. A. Ciazynska· 2 shared K. Qu· 2 shared L. C. James· 2 shared

Activity by Year

2016-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

C. E. Stone

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

The intracellular bacterium Orientia tsutsugamushi hijacks the adaptor protein BICD2 for dynein-based motility

G. Manigrasso, K. Saharat, C. Kullapanich, J. Boulanger, T. E. Morgan, H. Kramer, J. Salje, A. P. Carter

This study identifies how Orientia tsutsugamushi uses ScaC to recruit BICD2 for dynein-based motility, revealing a mechanism for bacterial transport within host cells.

bioRxiv · Apr 11, 2024 · PreprintMicrobiology

KIF1C activates and extends dynein movement through the FHF cargo adaptor

F. A. Ali, A. J. Zwetsloot, C. E. Stone, T. E. Morgan, R. F. Wademan, A. P. Carter, A. Straube

The paper shows KIF1C activates and enhances dynein movement via the FHF cargo adaptor, revealing a mechanism for motor co-dependency.

bioRxiv · Oct 26, 2023Cell Biology

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression

D. Salvador-Garcia, L. Jin, A. Hensley, M. Golcuk, E. Gallaud, S. Chaaban, F. Port, A. Vagnoni, V. J. Planelles-Herrero, M. A. McClintock, E. Derivery, A. P. Carter, R. Giet, M. Gur, A. Yildiz, S. L. Bullock

This study identifies a mutation in dynein that causes mitotic spindle arrest independent of the spindle assembly checkpoint, revealing a load-dependent role in anaphase progression.

bioRxiv · Aug 3, 2023 · PreprintCell Biology

Dynein and dynactin move long-range but are delivered separately to the axon tip

A. D. Fellows, M. Bruntraeger, T. Burgold, A. R. Bassett, A. P. Carter

The paper visualizes dynein and dynactin movement in axons, finding they move long-range together but are delivered separately to the axon tip.

bioRxiv · Jul 3, 2023Cell Biology

CryoET shows cofilactin filaments inside the microtubule lumen

C. Santos, S. L. Rogers, A. P. Carter

The paper uses cryoET to identify cofilactin filaments inside microtubule lumens in Drosophila cells and shows their association with cofilin activation.

bioRxiv · Mar 31, 2023 · PreprintCell Biology

Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike

K. Qu, Q. Chen, K. A. Ciazynska, B. Liu, X. Zhang, J. Wang, Y. He, J. Guan, J. He, T. Liu, A. P. Carter, X. Xiong, J. A. G. Briggs

This study engineers a SARS-CoV-2 spike protein with a disulfide bond to stabilize the locked conformation, revealing structural dynamics and the role of domain D in conformational changes and viral fitness.

PLOS Pathogens · Jul 29, 2022Peer-reviewedMicrobiology

Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin

E. d'Amico, M. Ud Din Ahmad, V. Cmentowski, M. Girbig, F. Mueller, S. Wohlgemuth, A. Brockmeyer, S. Maffini, P. Janning, I. R. Vetter, A. P. Carter, A. Perrakis, A. Musacchio

The paper shows Spindly adopts a closed conformation that blocks Dynein-Dynactin binding, and mutations induce an open state that enables interaction, with kinetochores promoting Spindly activation.

bioRxiv · Feb 2, 2022Biochemistry

A cryo-ET survey of intracellular compartments within mammalian axons

H. E. Foster, C. Ventura Santos, A. P. Carter

The paper uses cryo-ET to survey intracellular compartments in mammalian axons, revealing structural features and novel cargo types.

bioRxiv · Mar 29, 2021Cell Biology

A cryo-ET study of microtubules in axons

H. E. Foster, C. Ventura Santos, A. P. Carter

This study uses cryo-ET to examine microtubule structure in axons of mouse and Drosophila neurons, revealing structural differences and novel features of microtubule organization.

bioRxiv · Mar 29, 2021 · PreprintCell Biology

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

G. Papa, D. Mallery, A. Albecka, L. Welch, J. Cattin-Ortola, J. Luptak, D. Paul, H. T. McMahon, I. G. Goodfellow, A. P. Carter, S. Munro, L. C. James

bioRxiv · Aug 13, 2020Microbiology

A thermostable, closed, SARS-CoV-2 spike protein trimer.

X. Xiong, K. Qu, K. A. Ciazynska, M. Hosmillo, A. P. Carter, S. Ebrahimi, Z. Ke, S. H. W. Scheres, L. Bergamaschi, G. L. Grice, Y. Zhang, The CITIID-NIHR COVID-19 BioResource Collaboration, J. A. Nathan, S. Baker, L. C. James, , J. A. G. Briggs

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

bioRxiv · Jun 15, 2020Biochemistry

The Arp1/11 Minifilament of Dynactin Primes the Endosomal Arp2/3 Complex

A. I. Fokin, V. David, K. Oguievetskaia, E. Derivery, C. E. Stone, L. Cao, N. Rocques, N. Molinie, V. Henriot, M. Aumont-Nicaise, M. V. Hinckelmann, F. SAUDOU, C. Le Clainche, A. P. Carter, G. Romet-Lemonne, A. M. Gautreau

The paper shows that the WASH complex interacts with Dynactin and uncaps it, allowing the Arp1/11 minifilament to prime Arp2/3 complex-mediated actin branching at endosomes.

bioRxiv · May 29, 2020Cell Biology

DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes

H. T. Hoang, M. A. Schlager, A. P. Carter, S. L. Bullock

This study investigates how DYNC1H1 mutations affect dynein motility and links these defects to neurological diseases.

bioRxiv · Dec 9, 2016Cell Biology