M. Unnikrishnan

The staphylococcal type VII secretion system effector EsxC impacts daptomycin sensitivity through controlling bacterial cell envelope integrity

This study shows that the T7SS effector EsxC in S. aureus affects daptomycin sensitivity by modulating cell membrane integrity.

Dual RNA-seq identifies proteins and pathways modulated during Clostridioides difficile colonisation

This study uses dual RNA-seq to analyze gene expression changes in Clostridioides difficile and human gut epithelial cells during early infection, identifying modulated pathways and proteins involved in colonization.

The regulatory role of anti-sigma factor, RsbW, in Clostridioides difficile stress response, persistence and infection

This study investigates the role of RsbW in C. difficile stress response, showing that its absence leads to altered physiology, virulence, and gene regulation.

The safety profile of Bald's eyesalve for the treatment of bacterial infections

This paper evaluates the safety of Bald's eyesalve for treating bacterial infections using in vitro, ex vivo, and in vivo models, finding mild toxicity but potential for clinical testing.

Dissecting individual pathogen-commensal interactions within a complex gut microbiota community

This study develops an in vitro multi-species gut microbiota community to investigate pathogen-commensal interactions, finding that Bacteroides species inhibit Clostridiodes difficile growth.

The type VII secretion system protects Staphylococcus aureus against antimicrobial host fatty acids

This study shows that the type VII secretion system in Staphylococcus aureus protects against host antimicrobial fatty acids by maintaining membrane integrity and lipid homeostasis.

Probing host-anaerobe interactions in innovative human gut cellular models

This study develops human gut models to investigate interactions between anaerobic bacteria and the gut epithelium, showing C. difficile adhesion, spore production, and reduced growth in the presence of B. dorei.

Clostridioides difficile LuxS mediates inter-bacterial interactions within biofilms

This study shows that C. difficile LuxS/AI-2 mediates biofilm formation and inter-bacterial interactions with B. fragilis through differential metabolic and prophage regulation.