Monocyte-derived Prostaglandin E2 inhibits antigen-specific cutaneous immunity during ageing
E. S. Chambers, M. Vukmanovic-Stejic, B. B. Shih, H. Trahir, P. Subramanian, O. P. Devine, J. Glanville, D. Gilroy, M. Rustin, T. C. Freeman, N. A. Mabbott, A. N. Akbar
This study shows that inflammation from tissue injury in older adults reduces cutaneous immunity to VZV by recruiting monocytes that produce PGE2, which can be reversed with a p38-MAPK inhibitor.
bioRxiv · Apr 2, 2020Immunology