N. A. Mabbott

Dendritic Cells Overcome Cre/Lox Induced Gene Deficiency by Siphoning Material From Neighboring Cells Using Intracellular Monitoring - a Novel Mechanism of Antigen Acquisition

Dendritic cells maintain RNA and protein levels for conditionally deleted genes by siphoning material from neighboring cells using a novel mechanism.

Investigating the role of Mce proteins in Mycobacterium avium paratuberculosis infection

This study identifies Mce1A and Mce1D as effector molecules in MAP that enhance bacterial attachment and invasion in specific cell types.

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection

This study shows that chronic Trypanosoma brucei infection in mice causes meningeal lymphoid aggregates with autoreactive B cells and autoantibodies against brain antigens.

CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration following radiation-induced injury

This study identifies CSF1R-dependent macrophages as critical for epithelial regeneration after radiation-induced salivary gland injury.

Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia - plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection

This study uses single cell and spatial transcriptomics to identify microglia-plasma cell interactions in the mouse brain during chronic T. brucei infection.

Monocyte-derived Prostaglandin E2 inhibits antigen-specific cutaneous immunity during ageing

This study shows that inflammation from tissue injury in older adults reduces cutaneous immunity to VZV by recruiting monocytes that produce PGE2, which can be reversed with a p38-MAPK inhibitor.

Microbial Stimulation Reverses the Age-Related Decline in M Cells in Aged Mice

This study shows that microbial stimulation can reverse age-related decline in M cells in aged mice, improving their function and potential for oral vaccination.