M. W. Hess

Parkin R274W mutation affects muscle physiology via the PARIS-PGC-1α pathway

The paper investigates the effects of the Parkin R274W mutation on muscle physiology through the PARIS-PGC-1α pathway in mice.

The membrane activity of the amphibian Temporin B peptide analog TB_KKG6K sheds light on the mechanism that kills Candida albicans

This study investigates how the TB_KKG6K peptide kills Candida albicans by disrupting its membrane function, showing it causes depolarization, permeabilization, and subcellular damage.

Homeostatic feedback between lysosomal mTORC1 and mTORC2-AKT signaling controls nutrient uptake in brown adipose tissue

The paper shows that LAMTOR2 deletion in adipocytes causes insulin-independent AKT hyperphosphorylation, leading to increased glucose and fatty acid uptake and glycogen storage in brown adipose tissue.

A CRISPR-screen in intestinal epithelial cells identifies novel factors for polarity and apical transport

The paper identifies novel factors for epithelial polarization and apical transport using a CRISPR screen in human intestinal epithelial cells.

Rules for the self-assembly of ESCRT-III on endosomes

The authors withdrew their manuscript due to irreproducible results and unsupported conclusions about ESCRT-III self-assembly rules.

Multiple roles for the ESCRT machinery in maintaining plasma membrane homeostasis

This study investigates the role of ESCRT machinery in plasma membrane homeostasis using budding yeast, revealing its involvement in membrane tension regulation and sphingolipid metabolism through calcineurin/TORC2 signaling.