L. A. Huber

The negative adipogenesis regulator DLK1 is transcriptionally regulated by TIS7 (IFRD1) and translationally by its orthologue SKMc15 (IFRD2)

This paper identifies two regulatory mechanisms, transcriptional and translational, by which TIS7 and SKMc15 control DLK1 levels, impacting adipogenesis and obesity resistance.

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

This study shows that lysosome positioning influences PLEKHG3 localization and protrusive activity, but protrusion changes can occur without PLEKHG3.

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

The paper uses patient-derived organoids and phosphoproteomics to study signaling crosstalk in colorectal cancer and identify off-target effects of kinase inhibitors.

Homeostatic feedback between lysosomal mTORC1 and mTORC2-AKT signaling controls nutrient uptake in brown adipose tissue

The paper shows that LAMTOR2 deletion in adipocytes causes insulin-independent AKT hyperphosphorylation, leading to increased glucose and fatty acid uptake and glycogen storage in brown adipose tissue.

A CRISPR-screen in intestinal epithelial cells identifies novel factors for polarity and apical transport

The paper identifies novel factors for epithelial polarization and apical transport using a CRISPR screen in human intestinal epithelial cells.

Complementary α-arrestin - Rsp5 ubiquitin ligase complexes control selective nutrient transporter endocytosis in response to amino acid availability

The paper identifies complementary α-arrestin-Rsp5 complexes that regulate selective endocytosis of nutrient transporters based on amino acid availability.

G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules

This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.