Leveraging co-evolutionary insights and AI-based structural modeling to unravel receptor-peptide ligand-binding mechanisms
S. Snoeck, H. K. Lee, M. W. Schmid, K. W. Bender, M. J. Neeracher, A. D. Fernandez-Fernandez, J. Santiago, C. Zipfel
The paper identifies SCOOP-MIK2 binding mechanisms using in silico analysis, AlphaFold-Multimer, and experimental validation, revealing conserved binding pockets and their functional importance.
bioRxiv · Jan 18, 2024 · PreprintBiochemistry