H. K. Lee

Leveraging co-evolutionary insights and AI-based structural modeling to unravel receptor-peptide ligand-binding mechanisms

The paper identifies SCOOP-MIK2 binding mechanisms using in silico analysis, AlphaFold-Multimer, and experimental validation, revealing conserved binding pockets and their functional importance.

Arabidopsis LRR-MAL Receptor-like Kinases regulate intraspecific and interspecific pollen-stigma interactions

This study identifies new roles for Arabidopsis LRR-MAL receptor-like kinases in regulating early pollen-stigma interactions, supporting intraspecies fertilization and blocking interspecies hybridization.

A pectin-binding peptide with a structural and signaling role in the assembly of the plant cell wall

The paper identifies RALF22 as a peptide that functions both structurally and signaling in plant cell wall assembly, forming complexes with LRX1 and LLG1-FER to regulate cell expansion.

CEP signaling coordinates plant immunity with nitrogen status

This study identifies CEPs as immune-modulatory peptides in Arabidopsis that coordinate immunity with nitrogen status through receptor-dependent mechanisms.

Photonic-Plasmonic Coupling Enhanced Fluorescence Enabling Digital-Resolution Ultrasensitive Protein Detection

This paper enhances fluorescence detection using photonic-plasmonic coupling, achieving ultrasensitive protein detection with a 52-fold signal boost and 10 fg/ml detection limit.

An AI-assisted Tool For Efficient Prostate Cancer Diagnosis

This paper develops a deep learning pipeline to detect malignant glands in prostate cancer core needle biopsies, achieving high accuracy and providing heatmaps for pathologists.

Obtaining Spatially Resolved Tumor Purity Maps Using Deep Multiple Instance Learning In A Pan-cancer Study

This paper develops a deep multiple instance learning model to predict tumor purity from histopathology slides, showing spatial variation and improving sample selection for genomic analysis.

Single cell transcriptomic re-analysis of immune cells in bronchoalveolar lavage fluids reveals the correlation of B cell characteristics and disease severity of patients with SARS-CoV-2 infection

The paper reanalyzes scRNA-seq data to show that severe SARS-CoV-2 infection is associated with more activated B cells and pro-inflammatory macrophages.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

Two groups of Arabidopsis receptor kinases preferentially regulate the growth of intraspecies pollen tubes in the female reproductive tract

This study identifies two groups of Arabidopsis receptor kinases that regulate intraspecies pollen tube growth in the female reproductive tract and contribute to interspecies reproductive barriers.

Identification of a role for an E6-like 1 gene in early pollen-stigma interactions in Arabidopsis thaliana

This study identifies E6-like 1 (E6L1) as a novel gene in Arabidopsis thaliana involved in early pollen-stigma interactions, with mutants showing mild impairments in pollen hydration and seed set.

Daam2 Driven Degradation Of VHL Promotes Gliomagenesis

The paper identifies Daam2 as a factor promoting glioma formation by suppressing VHL expression through ubiquitination and degradation.