J. Santiago

Leveraging co-evolutionary insights and AI-based structural modeling to unravel receptor-peptide ligand-binding mechanisms

The paper identifies SCOOP-MIK2 binding mechanisms using in silico analysis, AlphaFold-Multimer, and experimental validation, revealing conserved binding pockets and their functional importance.

A pectin-binding peptide with a structural and signaling role in the assembly of the plant cell wall

The paper identifies RALF22 as a peptide that functions both structurally and signaling in plant cell wall assembly, forming complexes with LRX1 and LLG1-FER to regulate cell expansion.

CEP signaling coordinates plant immunity with nitrogen status

This study identifies CEPs as immune-modulatory peptides in Arabidopsis that coordinate immunity with nitrogen status through receptor-dependent mechanisms.

Arabidopsis Leucine Rich Repeat-Malectin Receptor Kinases in immunity triggered by cellulose and mixed-linked glucan oligosaccharides

This study identifies three Arabidopsis RLKs with LRR and MAL domains that recognize cellulose and MLG-derived oligosaccharides, triggering PTI, distinct from chitin recognition.

Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3

The paper identifies CTNIPs as a conserved family of plant signaling peptides and shows that HSL3 is their receptor, revealing an ancient signaling module involved in stress responses.

A subset of CB002 xanthine analogues bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

The paper identifies CB002 analogues that restore p53 signaling and target an S-phase checkpoint in p53-mutated tumors, inducing apoptosis and reducing proliferation without harming normal cells.

Structural basis for recognition of RALF peptides by LRX proteins during pollen tube growth

The paper reports the crystal structure of the LRX-RALF complex and shows RALF peptides function as folded, disulfide-stabilized proteins that bind LRXs with nanomolar affinity.

Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction

The paper presents crystal structures of two CrRLK1L receptor kinases involved in plant reproduction and identifies a novel protein-protein interaction interface.