J. D. Jones

Modular mechanisms of immune priming and growth inhibition mediated by plant effector-triggered immunity

This study identifies two distinct signalling modules in Arabidopsis that mediate different aspects of effector-triggered immunity, with implications for improving disease resistance in crops.

Conserved 5-methyluridine tRNA modification modulates ribosome translocation

This study identifies m5U54 as a conserved tRNA modification that modulates ribosome translocation and tRNA maturation.

ATR2Cala2 from Arabidopsis-infecting downy mildew requires 4 TIR-NLR immune receptors for full recognition

The paper identifies ATR2Cala2 as an effector recognized by four TIR-NLR immune receptors in Arabidopsis and shows their quantitative requirement for resistance to Hpa-Cala2.

The immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

Seed Longevity is Controlled by Metacaspases

The paper identifies metacaspases as regulators of seed longevity by modulating CDC48 activity through proteolytic control of its adaptor PUX.

Extensive immune receptor repertoire diversity in disease-resistant rice landraces

The paper examines NLR sequence diversity in rice landraces and modern varieties, finding higher diversity and balancing selection in landraces, suggesting their value for disease resistance.

The Solanum americanum pangenome and effectoromics reveal new resistance genes against potato late blight

The paper identifies novel resistance genes in Solanum americanum against Phytophthora infestans by analyzing genome variation and effector recognition.

Oligomerisation of a plant helper NLR requires cell-surface and intracellular immune receptor activation

This study shows that helper NLR NRG1 forms oligomeric complexes with EDS1 and SAG101 at the plasma membrane upon co-activation of intracellular and cell surface receptors.

Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation elongation

This study identifies and quantifies new mRNA modifications in S. cerevisiae and shows how they affect translation elongation.

Pangenomics facilitated with structural analysis reveals host NAD+ manipulation as a major virulence activity of bacterial effectors

This study identifies 13 type III effectors in Pseudomonas syringae with potential NADase activity, showing that NAD+ manipulation is a key virulence strategy in plant pathogens.

Effector-dependent activation and oligomerization of NRC helper NLRs by Rpi-amr3 and Rpi-amr1

This study shows that sensor NLRs Rpi-amr3 and Rpi-amr1 activate the helper NLR NRC2 to form a resistosome in response to Phytophthora effectors.

Concerted expansion and contraction of immune receptor gene repertoires in plant genomes

The paper examines immune receptor gene repertoires across 208 plant species, finding that cell-surface and intracellular receptor gene families co-evolve through concerted expansion and contraction.

Novel effector recognition capacity engineered into a paired NLR complex

The paper demonstrates a strategy to engineer plant immune receptors to recognize pathogen effectors by linking effector-dependent degradation to receptor function, resulting in SAP05-dependent resistance in Arabidopsis.

Perception of structurally distinct effectors by the integrated WRKY domain of a plant immune receptor.

This paper reveals how the WRKY domain of the Arabidopsis NLR receptor RRS1 recognizes structurally distinct bacterial effectors to initiate immunity.

Rpi-amr3 confers resistance to multiple Phytophthora species by recognizing a conserved RXLR effector

The paper identifies Rpi-amr3 as a resistance gene that recognizes a conserved RXLR effector from multiple Phytophthora species, conferring broad resistance.

The immune Rysto receptor recognizes a broadly conserved feature of potyviral coat proteins

The paper identifies the minimal CP fragment recognized by the Rysto receptor and shows its broad conservation across potyviruses, demonstrating its utility in crop resistance.

Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida recognition specificities

The paper identifies an allele of WRR4A in Arabidopsis that confers resistance to a virulent isolate of Albugo candida but reduces resistance to other effectors.

Chromatin accessibility landscapes activated by cell surface and intracellular immune receptors

The paper uses RNA-seq and ATAC-seq to show that both SRMI and IRMI increase chromatin accessibility at defense genes, revealing overlapping transcriptional regulatory mechanisms.

A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector

The paper identifies a new R gene, Rpi-amr1, from Solanum americanum that provides broad-spectrum resistance to Phytophthora infestans and defines its allelic diversity.

Mutual Potentiation of Plant Immunity by Cell-surface and Intracellular Receptors

This study shows that plant immune pathways activated by cell-surface and intracellular receptors mutually enhance each other to provide effective resistance against pathogens.

An rpw8 quadruple mutant of Arabidopsis Col-0 is partially compromised in bacterial and fungal resistance

The paper investigates the role of RPW8 in Arabidopsis immunity and development by generating a quadruple mutant, finding partial resistance impairment and delayed flowering.

High-resolution Expression Profiling of Selected Gene Sets during Plant Immune Activation

The paper develops a method to assess differential gene expression of selected genes during plant immune activation using sequence capture and RNA-seq.

Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity

The paper induces AvrRps4 expression in Arabidopsis to study RRS1/RPS4-mediated immunity without pathogen presence, revealing downstream immune responses.

Extreme resistance to Potato Virus Y in potato carrying the Rysto gene is mediated by a TIR-NLR immune receptor

This study identifies Rysto, a TIR-NLR receptor conferring extreme resistance to PVY in potato, and shows its function requires EDS1 and NRG1 proteins.