Author

C. J. Janse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 7 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

B. Franke-Fayard· 3 shared A. Abdelrahim· 1 shared A. Baeza Garcia· 1 shared A. Cortes· 1 shared A. El-Turabi· 1 shared A. F. El Hebieshy· 1 shared A. Hoffmann· 1 shared A. M. Blagborough· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

B. Franke-Fayard

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Vaccination by single dose sporozoite injection of blood stage attenuated malaria parasites

J. M. Sattler, L. Keiber, A. Abdelrahim, X. Zheng, M. Jaecklin, L. Zechel, C. A. Moreau, M. M. Fischer, C. J. Janse, A. Hoffmann, F. Hentzschel, F. Frischknecht

The paper identifies slow-growing, avirulent malaria parasite mutants that protect against disease after challenge with wild-type parasites.

EMBO Molecular Medicine · Aug 5, 2024Peer-reviewedCell Biology

Downregulation of the secreted protein with an altered thrombospondin repeat (SPATR) impacts the infectivity of malaria sporozoites

D. M. Costa, M. Sa, A. R. Teixeira, B. Perez-Cabezas, S. Golba, H. Sefiane-Djemaoune, P. Formaglio, B. Franke-Fayard, C. J. Janse, R. Amino, J. Tavares

This study shows that downregulating SPATR in malaria sporozoites impairs their motility, salivary gland invasion, and infectivity to mice.

bioRxiv · Mar 6, 2022 · PreprintMicrobiology

Malaria parasite evades mosquito immunity by glutaminyl cyclase mediated protein modification

S. K. Kolli, A. Molina-Cruz, T. Araki, F. J. A. v. Geurten, J. Ramesar, S. Chevalley-Maurel, H. J. Kroeze, S. Bezemer, C. de Korne, R. Withers, N. Raytselis, A. F. El Hebieshy, R. Q. Kim, M. Child, S. Kakuta, , C. J. Janse

This study shows that Plasmodium sporozoites use glutaminyl cyclase to modify surface proteins, evading mosquito immune detection and melanization.

bioRxiv · Jul 23, 2021Microbiology

Suppression of Plasmodium MIF-CD74 Signaling Protects Against Severe Malaria

A. Baeza Garcia, E. Siu, X. Du, L. Leng, B. Franke-Fayard, C. J. Janse, S. Howland, L. Renia, E. Lolis, R. Bucala

This study shows that blocking Plasmodium MIF-CD74 signaling protects against experimental cerebral malaria by preventing antigen presentation to CD8+ T cells.

bioRxiv · Feb 14, 2021Microbiology

Dissection-independent production of a protective whole-sporozoite malaria vaccine

J. Blight, K. A. Sala, E. Atcheson, H. Kramer, A. El-Turabi, E. Real, F. A. Dahalan, P. Bettencourt, E. Dickinson, E. Alves, A. M. Salman, C. J. Janse, F. Ashcroft, A. V. S. Hill, A. Reyes-Sandoval, , J. Baum

A four-step process isolates pure malaria sporozoites from mosquitoes without manual dissection, enabling a whole-parasite vaccine that provides sterilizing protection.

bioRxiv · Jun 22, 2020 · PreprintMicrobiology

Exposure to artemisinin at the trophozoite stage increases sexual conversion rates in the malaria parasite Plasmodium falciparum

H. P. Portugaliza, S. Miyazaki, F. J. A. Geurten, C. Pell, A. Rosanas-Urgell, C. J. Janse, A. Cortes

The paper shows that subcurative doses of dihydroartemisinin at the trophozoite stage increase sexual conversion in Plasmodium falciparum.

bioRxiv · Jun 15, 2020Microbiology

Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development

R. Caldelari, S. Dogga, M. W. Schmid, B. Franke-Fayard, C. J. Janse, D. Soldati-Favre, V. Heussler

This study performs transcriptome analysis of Plasmodium berghei exo-erythrocytic stages using RNA-seq, revealing stage-specific gene expression and metabolic differences.

bioRxiv · Feb 7, 2019Microbiology

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

L. Meerstein-Kessel, R. van der Lee, W. Stone, K. Lanke, D. A. Baker, P. Alano, F. Silvestrini, C. J. Janse, S. M. Khan, M. van de Vegte-Bolmer, W. Graumans, R. Siebelink-Stoter, T. W. Kooij, M. Marti, C. Drakeley, , M. A. Huynen

The paper integrates omics data to identify gametocyte-specific genes and transcripts in malaria parasites, finding novel biomarkers and validating their expression in natural infections.

bioRxiv · Jan 11, 2018Microbiology