Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection
Y. Rao, T.-Y. Wang, C. Qin, B. Espinosa, Q. Liu, A. Ekanayake, J. Zhao, A. C. Savas, S. Zhang, M. Zarinfar, Y. Liu, W. Zhu, N. A. Graham, T. Jiang, C. Zhang, P. Feng
This study identifies CTPS1 as a target for antiviral therapy by showing it suppresses interferon induction and promotes viral replication in SARS-CoV-2 infection.
bioRxiv · Feb 5, 2021Microbiology