N. A. Graham

Seabird traits and seasonality modulate nutrient dynamics of terrestrial and marine habitats on atolls

This study quantifies seabird nutrient contributions to atoll ecosystems, showing seasonal and taxon-specific effects on soil, plants, and seagrass nutrient levels.

Sustainable reference points for multispecies coral reef fisheries

The paper estimates sustainable reference points for multispecies coral reef fisheries using environmental data and assesses their status, finding that over half of jurisdictions have failed sustainability benchmarks.

Phospho-proteomic analysis of CAR-T cell signaling following activation by antigen-presenting cancer cells

This paper presents a label-free phospho-proteomic method to analyze CAR-T cell signaling activated by antigen-presenting cancer cells, revealing key pathways like MAPKs and CHK1.

Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15

The paper uses phospho-proteomics to show that RSK signaling is required for IL-2 and IL-15-induced proliferation in NK-92 cells.

Bayesian metamodeling of complex biological systems across varying representations

This paper introduces Bayesian metamodeling to integrate diverse models of biological systems, demonstrating its application to glucose-stimulated insulin secretion in pancreatic β-cells.

Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection

This study identifies CTPS1 as a target for antiviral therapy by showing it suppresses interferon induction and promotes viral replication in SARS-CoV-2 infection.

The landscape of metabolic pathway dependencies in cancer cell lines

This study identifies metabolic pathway dependencies in cancer cell lines by integrating gene expression, genetic loss-of-function, and pharmacological screening data, revealing context-specific vulnerabilities and drug sensitivity associations.

Global gut content data synthesis and phylogeny delineate reef fish trophic guilds

The paper introduces a quantitative framework to define trophic guilds using global gut content data and phylogenetic analysis, achieving 95% accuracy in classification.

Improved discrimination of asymmetric and symmetric arginine dimethylation by optimization of the normalized collision energy in LC-MS proteomics

Quantitative single cell heterogeneity profiling of patient derived tumor initiating gliomaspheres reveals unique signatures of malignancy and response

The paper uses single cell proteomic analysis to identify distinct signaling phenotypes in gliomaspheres, revealing EGFR and AKT/TORC1 signaling divergence and potential therapeutic targets.

MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis

This study shows that MOTS-c, a mitochondrial-encoded peptide, improves physical performance and muscle homeostasis across ages in mice and humans, suggesting mitochondrial genes regulate aging.