HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome
M. Asquith, P. R. Sternes, M.-E. Costello, L. Karstens, S. Diamond, T. M. Martin, T. D. Spector, K.-A. le Cao, J. T. Rosenbaum, M. A. Brown
This study identifies HLA-B27 and HLA-DRB1 alleles associated with altered gut microbiome composition in healthy individuals, suggesting a role for these alleles in influencing microbiome dynamics linked to ankylosing spondylitis and rheumatoid arthritis.
bioRxiv · Mar 5, 2019Microbiology