Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy and the host’s genotype upon microbiome composition
J. Yin, P. R. Sternes, M. Wang, M. Morrison, J. Song, T. Li, L. Zhou, X. Wu, F. He, J. Zhu, M. A. Brown, H. Xu
The paper uses shotgun metagenomics to analyze the gut microbiome in AS patients, finding enriched bacterial epitopes linked to HLA-B27 and effects of TNFi therapy and host genotype on microbiome composition.
bioRxiv · Mar 8, 2019Microbiology