Author

K.-A. Le Cao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

O. CHAPLEUR· 2 shared A. K. Enjeti· 1 shared A. K. Shah· 1 shared A. Mannan· 1 shared A. P. Barbour· 1 shared B. A. Spicer· 1 shared B. M. Harvey· 1 shared C. Bureau· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

O. CHAPLEUR

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Author profile →

5 papers

Recent·Most cited

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal.

D. R. Bond, S. M. Burnard, K. Uddipto, K. V. Hunt, B. M. Harvey, L. Steffens Reinhardt, C. Lawlor-O'Neill, E. A. Roper, S. Humphries, H. C. Murray, A. Mannan, M. D. Dun, C. de Bock, N. A. Bowden, A. K. Enjeti, , H. J. Lee

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.

bioRxiv · Jan 30, 2024Cancer Biology

Integrating independent microbial studies to build predictive models of anaerobic digestion inhibition by ammonia and phenol

S. Poirier, S. Dejean, C. Midoux, K.-A. Le Cao, O. CHAPLEUR

The paper integrates multiple microbial studies to identify robust biomarkers of anaerobic digestion inhibition by ammonia and phenol, achieving 90% accuracy in predicting inhibition using a multivariate model.

bioRxiv · Mar 16, 2020Microbiology

Integrative analyses to investigate the link between microbial activity and molecules degradation during anaerobic digestion

L. Cardona, K.-A. Le Cao, F. Puig-Castellvi, C. Bureau, C. Madigou, L. Mazeas, O. Chapleur

The paper investigates the link between microbial activity and substrate degradation in anaerobic digestion using integrated 16S rRNA and metabolomics data from co-digestion experiments.

bioRxiv · Feb 13, 2020Bioengineering

HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome

M. Asquith, P. R. Sternes, M.-E. Costello, L. Karstens, S. Diamond, T. M. Martin, T. D. Spector, K.-A. le Cao, J. T. Rosenbaum, M. A. Brown

This study identifies HLA-B27 and HLA-DRB1 alleles associated with altered gut microbiome composition in healthy individuals, suggesting a role for these alleles in influencing microbiome dynamics linked to ankylosing spondylitis and rheumatoid arthritis.

bioRxiv · Mar 5, 2019Microbiology

Serum glycoprotein biomarker validation for esophageal adenocarcinoma and application to Barrett’s surveillance

A. K. Shah, G. Hartel, I. Brown, C. Winterford, R. Na, K.-A. Le Cao, B. A. Spicer, M. Dunstone, W. A. Phillips, R. V. Lord, A. P. Barbour, D. I. Watson, V. Joshi, D. C. Whiteman, M. M. Hill

The paper validates serum glycoprotein biomarkers for esophageal adenocarcinoma and develops a panel for Barrett’s surveillance.

bioRxiv · Mar 13, 2018Biochemistry