Author

T. D. Spector

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:statistical model· 6 Research Focus:cell type annotation· 4 Assay:metagenomics· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

T. C. Martin· 3 shared A. Visconti· 2 shared C. J. Steves· 2 shared G. Lauc· 2 shared J. P. Walsh· 2 shared J. T. Bell· 2 shared M. Pezer· 2 shared N. D. Youngblut· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

T. C. Martin

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Characterisation of fasting and postprandial NMR metabolites: insights from the ZOE PREDICT 1 Study

K. M. Bermingham, M. Mazidi, P. W. Franks, T. Maher, A. M. Valdes, I. Linenberg, J. Wolf, G. Hadjigeorgiou, T. D. Spector, C. Menni, J. M. Ordovas, S. E. Berry, W. L. Hall

This study characterizes postprandial NMR metabolites in the ZOE PREDICT 1 cohort, showing significant inter- and intra-individual variability and strong correlations between fasting and postprandial measurements.

bioRxiv · Nov 14, 2022 · PreprintBiochemistry

Codiversification of gut microbiota with humans

T. A. Suzuki, L. Fitzstevens, V. T. Schmidt, H. Enav, K. Huus, M. Mbong, B. R. Adegbite, J. F. Zinsou, M. Esen, T. P. Velavan, A. A. Adegnika, L. H. Song, T. D. Spector, A. L. Muehlbauer, N. Marchi, , R. E. Ley

The paper identifies gut microbes that codiversified with human populations, showing vertical transmission and potential population-specific health benefits.

bioRxiv · Oct 12, 2021Evolutionary Biology

Genomic insights into adaptations of TMA-utilizing methanogens to diverse habitats including the human gut

J. de la Cuesta-Zuluaga, T. D. Spector, N. D. Youngblut, R. E. Ley

This study analyzes Methanomassiliicoccales genomes and metagenomes to understand their adaptation to diverse habitats, including the human gut, and their association with trimethylamine-producing bacteria.

bioRxiv · Sep 17, 2020Microbiology

The urinary tract microbiome in older women exhibits host genetics and environmental influences

A. S. Adebayo, G. Ackermann, R. C. E. Bowyer, P. M. Wells, G. Humphrey, R. Knight, T. D. Spector, C. J. Steves

This study identifies host genetic and environmental factors influencing the urinary microbiome in older women using twin data and metagenomic analysis.

bioRxiv · Nov 12, 2019Microbiology

Multi-omic analyses reveal antibody-dependent natural killer cell-mediated cytotoxicity in autoimmune thyroid diseases

T. C. Martin, K. M. Illieva, A. Visconti, M. Beaumont, S. J. Kiddle, R. J. B. Dobson, M. J. Mangino, E. M. Lim, M. Pezer, C. J. Steves, J. T. Bell, S. G. Wilson, G. Lauc, M. Roederer, J. P. Walsh, , S. N. Karagiannis

bioRxiv · Jun 6, 2019Immunology

HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome

M. Asquith, P. R. Sternes, M.-E. Costello, L. Karstens, S. Diamond, T. M. Martin, T. D. Spector, K.-A. le Cao, J. T. Rosenbaum, M. A. Brown

This study identifies HLA-B27 and HLA-DRB1 alleles associated with altered gut microbiome composition in healthy individuals, suggesting a role for these alleles in influencing microbiome dynamics linked to ankylosing spondylitis and rheumatoid arthritis.

bioRxiv · Mar 5, 2019Microbiology

Interplay between the human gut microbiome and host metabolism

A. Visconti, C. I. Le Roy, F. Rosa, N. Rossi, T. C. Martin, R. P. Mohney, L. Weizhong, E. de Rinaldis, J. T. Bell, J. C. Venter, K. E. Nelson, T. D. Spector, M. Falchi

This study examines the gut microbiome's metabolic interactions with the host, finding that functional pathways, not just species, significantly influence metabolites in blood and feces.

bioRxiv · Feb 27, 2019Microbiology

Decreased IgG core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases

T. C. Martin, M. Simurina, M. Zabczynska, M. Martinic Kavur, M. Rydlewska, M. Pezer, K. Kozlowska, A. Burri, M. Vilaj, R. Turek-Jabrocka, M. Krnjajic-Tadijanovic, M. Trofimiuk-Muldner, A. Litynska, A. Hubalewska-Dydejczyk, I. Trbojevic-Akmacic, , G. Lauc

The paper investigates the association between IgG core fucosylation and autoimmune thyroid diseases, finding decreased fucosylation is linked to increased ADCC and TPOAb levels.

bioRxiv · Jul 4, 2018Immunology