M.-G. Kang

Mitochondrial thermogenesis regulates heat-shock response in the nucleus

The paper shows mitochondrial thermogenesis generates heat that triggers a nuclear heat-shock response in mammalian cells.

Valosin-containing protein regulates the stability of amyotrophic lateral sclerosis-causing fused in sarcoma granules in cells by changing ATP concentrations inside the granules

This study shows VCP regulates FUS granule stability by consuming ATP inside the granules, acting as a timer to prevent persistent granules that lead to ALS pathology.

In vivo mitochondrial matrix proteome profiling reveals RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

Endomembrane systems are reorganized by ORF3a and Membrane (M) of SARS-CoV-2

This study identifies ORF3a and M proteins of SARS-CoV-2 as reorganizing the endoplasmic reticulum and mitochondrial-associated membrane, with potential therapeutic implications.

Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

The paper introduces iSLET, a method to track tissue-specific secretory proteins in live mice, demonstrating its use in labeling and identifying liver-specific secreted proteomes in blood plasma.